The usage of EMDEX® in a lactose-free reformulation of Cetirizine tablets


Spray-dried lactose is extensively used as filler and binder within the pharmaceutical {industry}, however many adults will not be capable of digest lactose…

Due to this fact, it’s indispensable to offer alternate options to lactose-containing medication with the intention to make them appropriate for lactose illiberal sufferers. EMDEX® is a promising substitute for spray-dried lactose because it has related powder and tableting properties. 

The purpose of this research was to check a lactose-free reformulation of cetirizine tablets. EMDEX® was used efficiently as a lactose substitute in cetirizine tablets leading to comparable pill properties when it comes to crushing power, disintegration time and dissolution profile. Moreover, the EMDEX® formulation was characterised by a wonderful powder circulate and low ejection forces in the course of the tableting course of. 

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European Pharmaceutical Review Issue 3 2022

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