Received hives? Maintain the steroids


Steroids Do Not Work to Control Itching From Hives

picture: A examine printed in <i>Annals of Emergency Medication</i> reveals that steroids don’t assist with the itching related to hives. Antihistamines do.
view extra 

Credit score: American Faculty of Emergency Physicians

WASHINGTON — Regardless of customary use for the itching related to urticaria (generally often called hives), prednisone (a steroid) provided no further reduction to emergency sufferers affected by hives than a placebo did, in accordance with a randomized, placebo-controlled, double-blind, parallel-group examine printed on-line yesterday in Annals of Emergency Medication (“Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Remedy of Acute Urticaria: A Randomized Double-Blind Medical Trial”).

“Prednisone is a powerful and nice drug for sure issues, however it’s no higher than antihistamine remedy for sufferers who’re itching with hives,” stated lead examine writer Caroline Barniol, MD, of the Centre Hospitalier Universitaire in Toulouse, France. “The antihistamine levocetirizine alone achieved full itching reduction inside 2 days for 76 p.c of sufferers. With the addition of prednisone, the reduction scores have been really worse.”

At 2-day follow-up, 62 p.c of sufferers handled with levocetirizine (an antihistamine) and prednisone had an “itch rating” of 0, whereas 76 p.c of these within the placebo group (levocetirizine and placebo) had an itch rating of 0. Thirty p.c of sufferers within the prednisone group and 24 p.c within the placebo group reported relapses.

Acute urticaria, or hives, is a reasonably widespread presentation within the emergency division. Itching is continuously related to hives and may intrude with every day actions and sleep. Worldwide tips printed in 2013 acknowledged {that a} quick course of oral corticosteroids could also be useful to scale back illness period for acute hives. Prednisone is often prescribed within the emergency division to deal with them, together with antihistamines.

“Regardless of the proof that second-generation H1-antihistamines deal with acute urticaria with out disturbing unwanted side effects, many physicians consider that corticosteroids are nonetheless the best remedy to acquire speedy symptom reduction,” stated Dr. Barniol. “Our outcomes don’t assist the addition of corticosteroid to antihistamines as a first-line remedy of uncomplicated acute hives. Even when short-term remedy with corticosteroids doesn’t trigger clinically vital toxicity, recurrent or long-term remedy might have deleterious results.”


Annals of Emergency Medication is the peer-reviewed scientific journal for the American Faculty of Emergency Physicians, the nationwide medical society representing emergency drugs. ACEP is dedicated to advancing emergency care by way of persevering with training, analysis, and public training. Headquartered in Dallas, Texas, ACEP has 53 chapters representing every state, in addition to Puerto Rico and the District of Columbia. A Authorities Providers Chapter represents emergency physicians employed by navy branches and different authorities companies. For extra data, go to

Disclaimer: AAAS and EurekAlert! should not accountable for the accuracy of stories releases posted to EurekAlert! by contributing establishments or for using any data by way of the EurekAlert system.


Supply hyperlink