Normal and double dose pantoprazole equally efficient

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Standard and double dose pantoprazole equally effective

(HealthDay)—For sufferers with gastric adenoma or early gastric most cancers, customary dose or double dose intravenous pantoprazole for 48 hours is equally efficient for prevention of delayed bleeding after endoscopic resection, in accordance with a research printed on-line Sept. 16 within the Journal of Gastroenterology and Hepatology.

For the research, Sung Woo Jung, M.D., from the College School of Medication in Seoul, South Korea, and colleagues enrolled 166 sufferers with gastric adenoma or early gastric most cancers. Topics had been randomized to obtain 40 mg pantoprazole each 24 hours or each 12 hours after an endoscopic process. On day two after endoscopic resection, a second-look endoscopy was carried out to check indicators of re-bleeding and ulcer standing between the teams. Information had been analyzed from 81 sufferers from the standard-dose group and 81 from the double-dose group.

On the second-look endoscopy, the researchers noticed no between-group distinction within the incidence of delayed bleeding occasions (1.3 versus 6.2 p.c for standard- and double-dose teams, respectively; P = 0.21) and bleeding ulcer (6.2 versus 3.9 p.c for standard- and double-dose teams, respectively; P = 0.69). No different variables correlated with delayed bleeding or bleeding ulcer on second-look endoscopy.

“Intravenous pantoprazole 40 mg each 24 hours or 12 hours for 2 days after endoscopic resection had been equally efficient for the prevention of delayed bleeding,” the authors write.


Magnifying endoscopy with enhanced imaging IDs gastric CA


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