Is Hydroxyzine Efficient for Treating Allergic reactions?


Hydroxyzine is a first-generation, sedating antihistamine, which has related negative effects to Benadryl. It’s marketed beneath the model names Atarax and Vistaril however can also be obtainable in generic type. Hydroxyzine was initially developed as a sedative throughout the Nineteen Fifties however was discovered to have important antihistamine properties.

This text explains how hydroxyzine works for treating allergy symptoms.

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Hydroxyzine for Allergic reactions

Healthcare suppliers generally prescribe hydroxyzine for the remedy of varied allergic and different circumstances, together with:


The dose of hydroxyzine will depend on which situation you’re utilizing it to deal with. Nonetheless, a typical dose is 25 to 50 milligrams each six hours.

Hydroxyzine can also be used for kids, though the dose is calculated primarily based on a baby’s weight. Nonetheless, remember the fact that the consequences of sedation and drowsiness might make a prescription for one of many second-generation antihistamines resembling Xyzal (levocetirizine) a greater choice.

How It Works

Hydroxyzine works by blocking the H1 receptor (histamine receptor), binding to them, thereby lowering histamine exercise.

What Is Histamine?

Histamine is a chemical the physique produces to guard you from dangerous substances. Nonetheless, with allergy symptoms, histamine overreacts when uncovered to allergens, leading to allergy signs.

Histamine permits extra fluid to flee from the capillaries into the tissues. When this happens, you expertise a runny nostril and watery eyes. Histamine additionally causes swelling, rashes, and itching.

Facet Results

Hydroxyzine additionally crosses into the mind, the place it may possibly trigger drowsiness and sedation. These results could also be helpful for treating anxiousness and insomnia. Nonetheless, they might be undesirable when treating allergy symptoms.

Hydroxyzine and Second Era Antihistamines

The energetic metabolite (a sort of molecule that outcomes from a metabolic course of) of hydroxyzine is cetirizine (Zyrtec), which is out there over-the-counter (OTC) as a low-sedating antihistamine.

The energetic isomer (two or extra substances with the identical molecular components) of cetirizine is levocetirizine (Xyzal), which is out there solely by prescription and has change into obtainable in generic type. It would not cross into the mind as readily as hydroxyzine, and subsequently it would not produce the identical sedation. It additionally doesn’t have the anti-anxiety results of hydroxyzine for a similar motive.

Zyrtec and Xyzal are higher for treating allergic rhinitis than hydroxyzine since they’ve fewer negative effects and an extended length of motion. They’re additionally efficient for treating hives and itching.

Zyrtec and Xyzal are ineffective for treating anxiousness, insomnia, nausea, and vomiting, circumstances for which healthcare suppliers prescribe hydroxyzine or different first-generation antihistamines. Regardless of hydroxyzine being a 50-year-old medicine, it nonetheless advantages numerous medical circumstances.

A assessment of research of Xyzal (levocetirizine) in 2009 discovered that 5 mg/d successfully lowered hay fever and urticaria (hives) signs and improved high quality of life.


Hydroxyzine is a first-generation antihistamine that treats allergy symptoms, hives, anxiousness, and insomnia. It really works by blocking H1 receptors to lower histamine. As a first-generation medicine, it causes sedation and drowsiness, which is useful for short-term remedy of hysteria, insomnia, and nausea.

A Phrase From Verywell

In case your allergy symptoms require medicine, it is best to know that hydroxyzine is an choice. Nonetheless, remember the fact that it causes sedation and drowsiness. So, if you wish to keep away from that facet impact, you could wish to first attempt a second-generation antihistamine, like Zyrtec or Xyzal.


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