Facet Results, Dosage, Makes use of, and Evaluate

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Sildenafil is a prescription drug. It comes within the type of a pill and suspension (liquid). Each are taken by mouth. It additionally is available in an intravenous (IV) kind, which is just given by a health care provider.

Sildenafil oral pill is on the market because the brand-name medicine Viagra and Revatio. It’s additionally out there as a generic drug. Generic medicine often value lower than the brand-name model. In some circumstances, they will not be out there in each power or kind because the brand-name drug.

Why it’s used

Sildenafil oral pill is used to deal with ED and PAH. Generic oral tablets can be found for each situations, however the brand-name medicine every deal with solely one of many situations.

  • Viagra: This drug is used to deal with ED. With ED, you’re unable to get or keep an erection.
  • Revatio: This drug is used to deal with PAH. With PAH, the blood stress in your lungs is simply too excessive. Your coronary heart has to work very arduous to pump blood into your lungs.

The way it works

Sildenafil belongs to a category of medicine known as phosphodiesterase sort 5 (PDE5) inhibitors. A category of medicine is a bunch of medicines that work in an analogous means. These medicine are sometimes used to deal with related situations.

Sildenafil works in numerous methods, relying on the situation it’s getting used to deal with.

  • For ED: Sildenafil works by rising blood stream to the penis. This helps you get or keep an erection. Sildenafil solely works for ED in case you’re sexually aroused.
  • For PAH: Sildenafil works by enjoyable the muscle mass and opening up the blood vessels in your lungs. This decreases the blood stress in your lungs. Sildenafil slows down the development of your sickness. It additionally makes you extra capable of train.

How sildenafil is used

How lengthy earlier than intercourse ought to I take advantage of sildenafil?

Sildenafil can be utilized as early as 4 hours earlier than intercourse and as late as half-hour earlier than intercourse. Nevertheless, it is strongly recommended to make use of this drug inside an hour earlier than intercourse.

How typically ought to I take sildenafil?

Sildenafil shouldn’t be taken for ED greater than as soon as in a 24-hour interval. However you probably have sure medical situations or are taking different medicine, your physician could advocate that you simply take this drug much less typically than as soon as a day.

Ought to I take sildenafil with meals?

Sildenafil may be taken with meals or with out meals. You will need to word that sure meals, significantly meals excessive in fats, may cause the drug to work extra slowly than regular.

Sildenafil uncomfortable side effects

Sildenafil oral pill doesn’t trigger drowsiness, however it could actually trigger different uncomfortable side effects, together with:

  • nosebleeds
  • complications
  • upset abdomen
  • flushing (reddening and warming of the face)
  • bother sleeping
  • fever
  • an erection that lasts longer than regular
  • respiratory an infection
  • nausea
  • vomiting
  • bronchitis
  • sore throat
  • runny nostril

If these results are gentle, they could go away inside a number of days or a few weeks. In the event that they’re extra extreme or don’t go away, discuss together with your physician or pharmacist.

Severe uncomfortable side effects

Name your physician straight away you probably have critical uncomfortable side effects. Name 911 in case your signs really feel life threatening or in case you assume you’re having a medical emergency. Severe uncomfortable side effects and their signs can embrace the next:

  • Low blood stress. Signs can embrace:
    • blurry imaginative and prescient
    • confusion
    • dizziness
    • fainting
    • lightheadedness
    • nausea or vomiting
    • sleepiness
    • weak point
  • Elevated shortness of breath or bother respiration
  • Priapism (an erection that lasts greater than 4 hours)
  • Imaginative and prescient issues. Signs can embrace:
    • sudden imaginative and prescient loss in a single or each eyes
  • Listening to issues. Signs can embrace:
    • sudden listening to loss
    • tinnitus (ringing in your ears)
    • dizziness
  • Coronary heart issues, comparable to coronary heart assault, stroke, or irregular coronary heart fee. Signs can embrace:
    • chest ache
    • shortness of breath
    • dizziness
    • bother talking
    • confusion
    • nausea or vomiting
    • feeling lightheaded

  • Priapism warning: This drug may cause priapism, which is an erection that received’t go away. In case you have an erection that lasts greater than 4 hours, name 911 or go to the closest emergency room. If it’s not handled straight away, this situation may cause everlasting harm to your penis.
  • Sudden imaginative and prescient loss warning: This drug may cause sudden imaginative and prescient loss in a single or each eyes. This generally is a signal of a critical eye drawback. If this happens, cease taking sildenafil and name your physician straight away.
  • Sudden listening to loss warning: This drug may cause listening to loss, tinnitus (ringing in your ears), or dizziness. In case you have sudden listening to loss with or with out tinnitus or dizziness, cease taking sildenafil and name your physician straight away.
  • Use in kids warning: Youngsters typically shouldn’t take sildenafil; nonetheless, there are cases the place the drug is taken into account one of the best remedy choice. Discuss together with your youngster’s physician to higher perceive the advantages and dangers related to this remedy choice.

Sildenafil oral pill can work together with different medicines, nutritional vitamins, or herbs chances are you’ll be taking. An interplay is when a substance adjustments the way in which a drug works. This may be dangerous or forestall the drug from working properly.

To assist keep away from interactions, your physician ought to handle your whole medicines fastidiously. Make sure to inform your physician about all medicines, nutritional vitamins, or herbs you’re taking. To learn the way this drug may work together with one thing else you’re taking, discuss together with your physician or pharmacist.

Examples of medicine that may trigger interactions with sildenafil are listed beneath.

Medication you shouldn’t use with sildenafil

Don’t take these medicine with sildenafil. Doing so may cause harmful results within the physique. Examples of those medicine embrace:

  • Nitrates, comparable to isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin.
    • Taking these medicine with sildenafil may cause your blood stress to drop all of the sudden to an unsafe stage.
  • Guanylate cyclase stimulators, comparable to riociguat.
    • Taking these medicine with sildenafil may cause your blood stress to drop all of the sudden to an unsafe stage.

Interactions that enhance your threat for uncomfortable side effects

Unwanted effects from sildenafil: Taking sildenafil with sure medicines raises your threat for uncomfortable side effects from sildenafil. It is because the quantity of sildenafil in your physique is elevated. Examples of those medicine embrace:

  • HIV medicine, comparable to ritonavir, indinavir, saquinavir, or atazanavir.
    • Elevated uncomfortable side effects can embrace low blood stress, dizziness, or imaginative and prescient issues. They will additionally embrace erections that last more than regular.
  • Sure antibiotics, comparable to clarithromycin or erythromycin.
    • Elevated uncomfortable side effects can embrace low blood stress, dizziness, or imaginative and prescient issues. They will additionally embrace erections that last more than regular.
  • Sure antifungals, comparable to ketoconazole or itraconazole.
    • Elevated uncomfortable side effects can embrace low blood stress, dizziness, or imaginative and prescient issues. They will additionally embrace erections that last more than regular.

Unwanted effects from different medicine: Taking sildenafil with sure medicines raises your threat for uncomfortable side effects from these medicine. Examples of those medicine embrace:

  • Alpha-blockers, comparable to terazosin, tamsulosin, doxazosin, alfuzosin, or silodosin.
    • Elevated uncomfortable side effects can embrace a drop in blood stress, or fainting.
  • Blood stress medicine, comparable to amlodipine.
    • Elevated uncomfortable side effects can embrace blood stress that’s too low.
  • Different medicine for erectile dysfunction, comparable to avanafil, tadalafil, or vardenafil.
    • Elevated uncomfortable side effects can embrace low blood stress or erections that last more than regular

Disclaimer: Our purpose is to give you probably the most related and present info. Nevertheless, as a result of medicine work together in another way in every individual, we can not assure that this info contains all doable interactions. This info is just not an alternative choice to medical recommendation. All the time communicate together with your healthcare supplier about doable interactions with all prescribed drugs, nutritional vitamins, herbs and dietary supplements, and over-the-counter medicine that you’re taking.

This drug comes with a number of warnings.

Allergy warning

Sildenafil may cause a extreme allergic response. Signs can embrace:

  • bother respiration
  • swelling of your throat or tongue

In case you develop these signs, name 911 or go to the closest emergency room.

Don’t take this drug once more in case you’ve ever had an allergic response to it. Taking it once more might be deadly (trigger loss of life).

Alcohol interplay warning

Using drinks that include alcohol raises your threat for low blood stress from sildenafil. In case you drink alcohol, discuss together with your physician. It’s possible you’ll must have your blood stress monitored whilst you take this drug.

Warnings for folks with sure well being situations

For folks with coronary heart issues: This drug can decrease your blood stress. In case you’ve had sure coronary heart issues within the final 6 months, ask your physician whether or not this drug is protected for you. These issues embrace a coronary heart assault, stroke, or life threatening coronary heart rhythm drawback. Additionally discuss together with your physician you probably have a low or excessive resting blood stress, or a historical past of coronary heart failure or coronary artery illness.

For folks with pulmonary veno-occlusive illness (PVOD): Taking this drug could worsen your coronary heart perform. You shouldn’t take this drug.

For folks with eye issues: This drug could trigger sudden lack of imaginative and prescient in a single or each eyes. This can be an indication of non-arteritic anterior ischemic optic neuropathy (NAION). In case you’ve already had NAION or have crowded optic disc, you might have the next threat for NAION and imaginative and prescient adjustments with this drug.

For folks with issues with the form of their penis: In case you have an issue with the form of your penis, comparable to Peyronie’s illness, this drug raises your threat for having an erection that lasts greater than 4 hours.

For folks with a historical past of abdomen ulcers or bleeding: This drug raises your threat for abdomen bleeding, ulcers, or small holes within the lining of your digestive system. These occasions may be deadly (trigger loss of life). They will occur at any time, with or with out signs.

For folks with sickle cell anemia: This drug could trigger a typical painful complication of sickle cell anemia known as vaso-occlusive disaster. In case you have sickle cell anemia, ask your physician whether or not this drug is protected for you.

Warnings for different teams

For pregnant girls: Analysis in animals has not proven a threat to the fetus when the mom takes the drug. Nevertheless, there aren’t sufficient research completed in people utilizing the drug for PAH to indicate if the drug poses a threat to the fetus.

Discuss together with your physician in case you’re pregnant or planning to turn into pregnant. It seems unlikely that this drug will hurt a being pregnant. Nevertheless, this drug ought to solely be used throughout being pregnant if clearly wanted.

Viagra or generic sildenafil for ED shouldn’t be utilized in girls.

For ladies who’re breastfeeding: When used for PAH, sildenafil could go into breast milk and will trigger uncomfortable side effects in a toddler who’s breastfed. Discuss together with your physician in case you breastfeed your youngster. It’s possible you’ll must resolve whether or not to cease breastfeeding or cease taking this treatment.

Viagra or generic sildenafil for ED shouldn’t be utilized in girls.

For seniors: The kidneys, liver, or coronary heart of older adults could not work in addition to they used to. This may trigger your physique to course of medicine extra slowly. In consequence, the next quantity of a drug stays in your physique for an extended time. This raises your threat for uncomfortable side effects.

For kids: This drug isn’t advisable in kids youthful than 18 years. In a single research, kids with PAH who took this drug had an elevated likelihood for loss of life.

All doable dosages and drug kinds will not be included right here. Your dosage, drug kind, and the way typically you’re taking the drug will rely upon:

  • your age
  • the situation being handled
  • how extreme your situation is
  • different medical situations you might have
  • the way you react to the primary dose

Dosage for erectile dysfunction (ED)

Generic: Sildenafil

  • Kind: oral pill
  • Strengths: 25 mg, 50 mg, 100 mg

Model: Viagra

  • Kind: oral pill
  • Strengths: 25 mg, 50 mg, 100 mg

Grownup dosage (ages 18–64 years)

  • Typical dosage: 50 mg, taken as wanted about 1 hour earlier than sexual exercise. It may be taken half-hour to 4 hours earlier than sexual exercise.
  • Most dosage: 100 mg as soon as per day.

Youngster dosage (ages 0–17 years)

This drug has not been confirmed to be protected or efficient in kids youthful than 18 years.

Senior dosage (ages 65 years and older)

The kidneys, liver, or coronary heart of older adults could not work in addition to they used to. This may trigger your physique to course of medicine extra slowly. In consequence, the next quantity of a drug stays in your physique for an extended time. This raises your threat of uncomfortable side effects.

Your physician could begin you on a lowered dosage of sildenafil. This might help forestall ranges of this drug from increase in your physique.

Dosage for pulmonary arterial hypertension (PAH)

Generic: Sildenafil

  • Kind: oral pill
  • Strengths: 20 mg

Model: Revatio

  • Kind: oral pill
  • Strengths: 20 mg

Grownup dosage (ages 18–64 years)

  • Typical dosage: 5 or 20 mg, taken 3 times per day about 4 to six hours aside
  • Most dosage: 20 mg, taken 3 times per day about 4 to six hours aside

Youngster dosage (ages 0–17 years)

This drug shouldn’t be utilized in kids youthful than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys, liver, or coronary heart of older adults could not work in addition to they used to. This may trigger your physique to course of medicine extra slowly. In consequence, the next quantity of a drug stays in your physique for an extended time. This raises your threat for uncomfortable side effects.

Your physician could begin you on a lowered dosage of sildenafil. This might help forestall ranges of this drug from increase in your physique.

Disclaimer: Our purpose is to give you probably the most related and present info. Nevertheless, as a result of medicine have an effect on every individual in another way, we can not assure that this checklist contains all doable dosages. This info is just not an alternative choice to medical recommendation. All the time communicate together with your physician or pharmacist about dosages which can be best for you.

Sildenafil oral pill is used for short-term remedy of ED and long-term remedy of PAH. It comes with critical dangers in case you don’t take it as prescribed.

In case you cease taking the drug all of the sudden or don’t take it in any respect:

  • For ED: Your ED signs received’t enhance.
  • For PAH: Your situation received’t enhance and will worsen. Additionally, you received’t be capable of train.

In case you miss doses or don’t take the drug on schedule:

  • For ED: Your ED signs received’t enhance.
  • For PAH: This treatment could not work as properly or could cease working utterly. For this drug to work properly, a specific amount must be in your physique always.

In case you take an excessive amount of: You can have harmful ranges of the drug in your physique. Signs of an overdose of this drug can embrace:

  • low blood stress
  • fainting
  • dizziness
  • imaginative and prescient issues
  • listening to issues
  • upset abdomen
  • chest ache

In case you assume you’ve taken an excessive amount of of this drug, name your physician or native poison management heart. In case your signs are extreme, name 911 or go to the closest emergency room straight away.

What to do in case you miss a dose:

  • For ED: Take your dose half-hour to 4 hours earlier than your subsequent sexual exercise.
  • For PAH: Take your dose as quickly as you bear in mind. However in case you bear in mind only a few hours earlier than your subsequent scheduled dose, take just one dose. By no means attempt to catch up by taking two doses directly. This might lead to harmful uncomfortable side effects.

How one can inform if the drug is working:

  • For ED: It’s best to be capable of get and keep an erection when sexually aroused.
  • For PAH: It’s best to be capable of train extra simply. Your physician will even test you to find out if this drug is working.

Hold these concerns in thoughts in case your physician prescribes sildenafil for you.

Normal

  • You possibly can take this drug with or with out meals.
  • You possibly can reduce or crush the pill.
  • Once you take the drug depends upon the situation being handled:
    • For ED: You possibly can take this drug at any time of day.
    • For PAH: Take this drug 3 times per day about 4–6 hours aside. Take it on the similar time day-after-day.

Storage

  • Retailer sildenafil tablets at room temperature between 59°F and 86°F (15°C and 30°C).
  • Hold sildenafil tablets away from gentle.
  • Don’t retailer this treatment in moist or damp areas, comparable to bogs.

Refills

A prescription for this treatment is refillable. You shouldn’t want a brand new prescription for this treatment to be refilled. Your physician will write the variety of refills approved in your prescription.

Journey

When touring together with your treatment:

  • All the time carry your treatment with you. When flying, by no means put it right into a checked bag. Hold it in your carry-on bag.
  • Don’t fear about airport X-ray machines. They will’t hurt your treatment.
  • It’s possible you’ll want to indicate airport employees the pharmacy label in your treatment. All the time carry the unique prescription-labeled container with you.
  • Don’t put this treatment in your automotive’s glove compartment or depart it within the automotive. Make sure to keep away from doing this when the climate may be very scorching or very chilly.

Scientific monitoring

In case you’re taking this drug for PAH, your physician could monitor your blood stress and pulse repeatedly.

Availability

Not each pharmacy shares this drug. When filling your prescription, you’ll want to name forward to ensure your pharmacy carries it.

Prior authorization

Many insurance coverage corporations require prior authorization for this drug. This implies your physician could must get approval out of your insurance coverage firm earlier than your insurance coverage firm pays for the prescription.

Why is sildenafil prescribed? Sildenafil underneath the model identify Viagra is prescribed to deal with erectile dysfunction by rising blood stream to the penis throughout arousal. Sildenafil underneath the model identify Revatio is commonly prescribed to assist adults with PAH get extra train by treating their situation.

What if I overlook to take it? In case you are taking Revatio and also you overlook to take your scheduled dose, take it as quickly as doable. Nevertheless, you must by no means double your dosage. In case you utterly miss a dose and it’s time for the following dose, skip the one you missed.

Are there any security measures I ought to take earlier than utilizing this drug? Like most medicines, there are precautions you must take earlier than utilizing this drug. Be sure you discuss together with your physician about:

  • any treatment allergy symptoms you might have
  • every other medicine, medicines, herbs, or dietary supplements you’re taking or plan to take
  • any medical situations or surgical procedures you may have or plan to have
  • in case you are pregnant or plan to turn into pregnant

There are different medicine out there to deal with your situation. Some could also be higher suited to you than others. Discuss together with your physician about different drug choices which will give you the results you want.

Sildenafil vs. tadalafil

Sildenafil and tadalafil are alike as a result of they each can deal with ED and PAH. Nevertheless, tadalafil has a number of distinctions from sildenafil.

Tadalafil is the generic identify for the erectile dysfunction drug Cialis. There are two variations of the drug:

  • a every day dosage model
  • a model that may be taken as wanted

Cialis 5-mg every day dosing is the one PDE5 inhibitor dose accredited for treating an enlarged prostate; bettering ED signs is an added good thing about the every day dose.

Due to the “as wanted” model of tadalafil, some customers could discover this selection extra handy. Additionally, tadalafil tends to:

  • work quicker
  • not be affected by meals
  • last more

The draw back, nonetheless, is that uncomfortable side effects are inclined to last more too.

What’s the distinction between sildenafil and Viagra?

The primary distinction between generic sildenafil and Viagra is advertising and marketing. The primary ingredient in Viagra is sildenafil, which means that the medicine are primarily the identical.

Nevertheless, Viagra is marketed and prescribed strictly for erectile dysfunction, whereas generic sildenafil may be prescribed for PAH as properly.

Viagra is also called “the little blue capsule” due to its blue coloration, whereas generic sildenafil tends to be a white coloration.

Disclaimer: Healthline has made each effort to make sure that every one info is factually appropriate, complete, and updated. Nevertheless, this text shouldn’t be used as an alternative choice to the information and experience of a licensed healthcare skilled. It’s best to at all times seek the advice of your physician or different healthcare skilled earlier than taking any treatment. The drug info contained herein is topic to alter and isn’t supposed to cowl all doable makes use of, instructions, precautions, warnings, drug interactions, allergic reactions, or adversarial results. The absence of warnings or different info for a given drug doesn’t point out that the drug or drug mixture is protected, efficient, or acceptable for all sufferers or all particular makes use of.

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